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Title:

In vivo measurement of apparent diffusion coefficients of hyperpolarized ¹³C-labeled metabolites.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Søgaard, Lise Vejby; Schilling, Franz; Janich, Martin A; Menzel, Marion I; Ardenkjaer-Larsen, Jan Henrik
Abstract:
The combination of hyperpolarized MRS with diffusion weighting (dw) allows for determination of the apparent diffusion coefficient (ADC), which is indicative of the intra- or extracellular localization of the metabolite. Here, a slice-selective pulsed-gradient spin echo sequence was implemented to acquire a series of dw spectra from rat muscle in vivo to determine the ADCs of multiple metabolites after a single injection of hyperpolarized [1- ¹³C]pyruvate. An optimal control optimized universal-...     »
Journal title abbreviation:
NMR Biomed
Year:
2014
Journal volume:
27
Journal issue:
5
Pages contribution:
561-9
Language:
eng
Fulltext / DOI:
doi:10.1002/nbm.3093
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24664927
Print-ISSN:
0952-3480
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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