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Title:

Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease.

Document type:
journal article
Author(s):
Alexopoulos, Panagiotis; Kriett, Laura; Haller, Bernhard; Klupp, Elisabeth; Gray, Katherine; Grimmer, Timo; Laskaris, Nikolaos; Förster, Stefan; Perneczky, Robert; Kurz, Alexander; Drzezga, Alexander; Fellgiebel, Andreas; Yakushev, Igor; Alzheimer's Disease Neuroimaging Initiative
Abstract:
New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen ?, 0.24-0.34), in accord wit...     »
Journal title abbreviation:
Alzheimers Dement
Year:
2014
Journal volume:
10
Journal issue:
6
Pages contribution:
684-9
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24857233
Print-ISSN:
1552-5260
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Medizinische Statistik und Epidemiologie; Nuklearmedizinische Klinik und Poliklinik
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