C-reactive protein and prognosis in women and men with coronary artery disease after percutaneous coronary intervention.

Ndrepepa, Gjin; Braun, Siegmund; Cassese, Salvatore; Fusaro, Massimiliano; King, Lamin; Kastrati, Adnan; Schmidt, Roland

doi:10.1016/j.carrev.2013.07.002

2013

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Title:: C-reactive protein and prognosis in women and men with coronary artery disease after percutaneous coronary intervention.
Document type:: Journal Article; Article
Author(s):: Ndrepepa, Gjin; Braun, Siegmund; Cassese, Salvatore; Fusaro, Massimiliano; King, Lamin; Kastrati, Adnan; Schmidt, Roland
Abstract:: Sex-based differences in the association between C-reactive protein (CRP) and cardiovascular events in patients with coronary artery disease (CAD) are incompletely investigated. We investigated whether there are gender differences in the association between CRP and outcome in patients with CAD after percutaneous coronary intervention (PCI).This study included 13,170 consecutive patients with CAD: 10,098 men and 3072 women. CRP was measured on admission in all patients. The primary outcome was 1-year mortality.CRP level (median [25th-75th percentiles]) was higher in women than in men (3.08 [1.30-8.37] mg/L vs 2.30 [0.92-6.47] mg/L; P<0.001). CRP was >3mg/L in 4250 men (42.1%) and 1554 women (50.6%; P<0.001). One-year mortality was 4.9% (n=641 deaths). Deaths occurred in 318 men with CRP >3mg/L and 122 men with CRP <=3mg/L (mortality estimates 7.7% and 2.1%, P<0.001) and in 154 women with CRP >3mg/L and 47 women with CRP <=3mg/L (mortality estimates 10.1% and 3.2%, P<0.001). After adjustment in the Cox model, CRP was associated with increased risk of mortality in women (adjusted hazard ratio [HR]=1.03, 95% confidence interval [CI] 1.01-1.04, P<0.001 for each 5mg/L increase) and in men (adjusted HR=1.02 [1.01-1.03], P<0.001, for each 5mg/L increase). CRP predicted mortality with an area under the receiver-operating characteristic curve =0.721, [0.683-0.760] in women and 0.732, [0.707-0.757] in men (P=0.659).Elevated CRP levels provide similar prognostic information in men and women with CAD after PCI which is independent and supplementary to that provided by conventional cardiovascular risk factors.
Journal title abbreviation:: Cardiovasc Revasc Med
Year:: 2013
Journal volume:: 14
Journal issue:: 5
Pages contribution:: 264-9
Language:: eng
Fulltext / DOI:: doi:10.1016/j.carrev.2013.07.002
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/23969223
Print-ISSN:: 1553-8389
TUM Institution:: Institut für Laboratoriumsmedizin (keine SAP-Zuordnung!); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Institut für Laboratoriumsmedizin (DHM) (Prof. Holdenrieder)2013

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2013