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Title:

Modeling long-QT syndromes with iPS cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Article
Author(s):
Sinnecker, Daniel; Goedel, Alexander; Dorn, Tatjana; Dirschinger, Ralf J; Moretti, Alessandra; Laugwitz, Karl-Ludwig
Abstract:
The generation of induced pluripotent stem cells (iPSC) from human somatic cells bears the possibility to generate patient-specific stem cell lines which can serve as a theoretically unlimited source of somatic cells carrying the genotype of the patients. Different types of the long-QT syndrome have been studied by analyzing the phenotype of cardiomyocytes generated from patient-specific iPSC lines. Major aspects of the pathophysiology of long-QT syndrome, like prolonged action potentials, arrhy...     »
Journal title abbreviation:
J Cardiovasc Transl Res
Year:
2013
Journal volume:
6
Journal issue:
1
Pages contribution:
31-6
Language:
eng
Fulltext / DOI:
doi:10.1007/s12265-012-9416-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23076501
Print-ISSN:
1937-5387
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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