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Titel:

Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Mehta, Divya; Heim, Katharina; Herder, Christian; Carstensen, Maren; Eckstein, Gertrud; Schurmann, Claudia; Homuth, Georg; Nauck, Matthias; Völker, Uwe; Roden, Michael; Illig, Thomas; Gieger, Christian; Meitinger, Thomas; Prokisch, Holger
Abstract:
Genome-wide association studies (GWASs) have uncovered susceptibility loci for a large number of complex traits. Functional interpretation of candidate genes identified by GWAS and confident assignment of the causal variant still remains a major challenge. Expression quantitative trait (eQTL) mapping has facilitated identification of risk loci for quantitative traits and might allow prioritization of GWAS candidate genes. One major challenge of eQTL studies is the need for larger sample numbers...     »
Zeitschriftentitel:
Eur J Hum Genet
Jahr:
2013
Band / Volume:
21
Heft / Issue:
1
Seitenangaben Beitrag:
48-54
Sprache:
eng
Volltext / DOI:
doi:10.1038/ejhg.2012.106
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22692066
Print-ISSN:
1018-4813
TUM Einrichtung:
Institut für Humangenetik
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