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Titel:

Dilution of candidates: the case of iron-related genes in restless legs syndrome.

Dokumenttyp:
Journal Article; Article
Autor(en):
Oexle, K; Schormair, B; Ried, JS; Czamara, D; Heim, K; Frauscher, B; Högl, B; Trenkwalder, C; Martin Fiedler, G; Thiery, J; Lichtner, P; Prokisch, H; Specht, M; Müller-Myhsok, B; Döring, A; Gieger, C; Peters, A; Wichmann, HE; Meitinger, T; Winkelmann, J
Abstract:
Restless legs syndrome (RLS) is a common multifactorial disease. Some genetic risk factors have been identified. RLS susceptibility also has been related to iron. We therefore asked whether known iron-related genes are candidates for association with RLS and, vice versa, whether known RLS-associated loci influence iron parameters in serum. RLS/control samples (n = 954/1814 in the discovery step, 735/736 in replication 1, and 736/735 in replication 2) were tested for association with SNPs located...     »
Zeitschriftentitel:
Eur J Hum Genet
Jahr:
2013
Band / Volume:
21
Heft / Issue:
4
Seitenangaben Beitrag:
410-4
Sprache:
eng
Volltext / DOI:
doi:10.1038/ejhg.2012.193
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22929029
Print-ISSN:
1018-4813
TUM Einrichtung:
Institut für Humangenetik; Neurologische Klinik und Poliklinik
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