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Titel:

(213)Bi-anti-EGFR radioimmunoconjugates and X-ray irradiation trigger different cell death pathways in squamous cell carcinoma cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Pickhard, A; Piontek, G; Seidl, C; Kopping, S; Blechert, B; Mißlbeck, M; Brockhoff, G; Bruchertseifer, F; Morgenstern, A; Essler, M
Abstract:
Treatment of patients with squamous cell carcinoma of head and neck is hampered by resistance of tumor cells to irradiation. Additional therapies enhancing the effect of X-ray irradiation may be beneficial. Antibodies targeting EGFR have been shown to improve the efficacy of radiation therapy. Therefore, we analyzed cytotoxicity of (213)Bi-anti-EGFR immunoconjugates in combination with X-ray irradiation.The monoclonal anti-EGFR antibody matuzumab was coupled to CHX-A"-DTPA forming stable complex...     »
Zeitschriftentitel:
Nucl Med Biol
Jahr:
2014
Band / Volume:
41
Heft / Issue:
1
Seitenangaben Beitrag:
68-76
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.nucmedbio.2013.09.010
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24210808
Print-ISSN:
0969-8051
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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