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Title:

The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism.

Document type:
Journal Article
Author(s):
Pickhard, Anja; Siegl, Michael; Baumann, Alexander; Huhn, Maximilian; Wirth, Markus; Reiter, Rudolf; Rudelius, Martina; Piontek, Guido; Brockhoff, Gero
Abstract:
The aim of this study was to evaluate the efficiency of cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function of Aurora kinase polymorphism in HNSCC cell lines.First, protein expression of Aurora kinase A / B and EGFR and Aurora kinase A polymorphism were studied in tumour samples. The survival and proliferation of Aurora kinase A homo- (Cal27) and heterozygous (HN) HNSCC cell lines was evaluated using a colony formation assay and a flow cytometric assay. Also, aneu...     »
Journal title abbreviation:
Oncotarget
Year:
2014
Journal volume:
5
Journal issue:
14
Pages contribution:
5428-38
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24980817
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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