Benutzer: Gast  Login
Mehr Felder
Einfache Suche
Titel:

The response of head and neck squamous cell carcinoma to cetuximab treatment depends on Aurora kinase A polymorphism.

Dokumenttyp:
Journal Article
Autor(en):
Pickhard, Anja; Siegl, Michael; Baumann, Alexander; Huhn, Maximilian; Wirth, Markus; Reiter, Rudolf; Rudelius, Martina; Piontek, Guido; Brockhoff, Gero
Abstract:
The aim of this study was to evaluate the efficiency of cetuximab-based anti-EGFR treatment and Aurora kinase A / B knockdown as a function of Aurora kinase polymorphism in HNSCC cell lines.First, protein expression of Aurora kinase A / B and EGFR and Aurora kinase A polymorphism were studied in tumour samples. The survival and proliferation of Aurora kinase A homo- (Cal27) and heterozygous (HN) HNSCC cell lines was evaluated using a colony formation assay and a flow cytometric assay. Also, aneu...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2014
Band / Volume:
5
Heft / Issue:
14
Seitenangaben Beitrag:
5428-38
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24980817
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
 BibTeX