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Title:

Osteogenic differentiation of mesenchymal stem cells in fibrin-hydroxyapatite matrix in a 3-dimensional mesh scaffold.

Document type:
Journal Article
Author(s):
Jung, Ole; Hanken, Henning; Smeets, Ralf; Hartjen, Philip; Friedrich, Reinhard E; Schwab, Bettina; Gröbe, Alexander; Heiland, Max; Al-Dam, Ahmed; Eichhorn, Wolfgang; Sehner, Susanne; Kolk, Andreas; Wöltje, Michael; Stein, Jamal M
Abstract:
To explore the feasibility of culturing mesenchymal stem cells in an hydroxyapatite-fibrin matrix held by a mesh scaffold and inducing osteogenic differentiation of these cells. The aim was to obtain bone-material in vitro in a desired form.Rat mesenchymal stem cells were mixed with fibrin and nanocrystalline hydroxyapatite in tubular scaffolds constructed from a poly(L-lactic acid) mesh, and cultured under standard and osteogenic differentiating conditions. Cell viability, cytotoxicity and alka...     »
Journal title abbreviation:
In Vivo
Year:
2014
Journal volume:
28
Journal issue:
4
Pages contribution:
477-82
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24982212
Print-ISSN:
0258-851X
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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