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Title:

Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Liffers, Sven-T; Tilkorn, Daniel J; Stricker, Ingo; Junge, Christoph Günter; Al-Benna, Sammy; Vogt, Markus; Verdoodt, Berlinda; Steinau, Hans-U; Tannapfel, Andrea; Tischoff, Iris; Mirmohammadsadegh, Alireza
Abstract:
Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas. Here, we evaluated the effect of salinomycin on sarcoma cell lines, whereby salinomycin mono- and combination treatment with...     »
Journal title abbreviation:
BMC Cancer
Year:
2013
Journal volume:
13
Pages contribution:
490
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2407-13-490
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24144362
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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