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Title:

Impact of STAT/SOCS mRNA expression levels after major injury.

Document type:
Journal Article
Author(s):
Brumann, M; Matz, M; Kusmenkov, T; Stegmaier, J; Biberthaler, P; Kanz, K-G; Mutschler, W; Bogner, V
Abstract:
Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family.20 polytraumatized patients were included. Blood samples were drawn 0 h-72 h after trauma; mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3 were quantified by qPCR.IL-10 mRNA expression increased significantly in the early postt...     »
Journal title abbreviation:
Mediators Inflamm
Year:
2014
Journal volume:
2014
Pages contribution:
749175
Fulltext / DOI:
doi:10.1155/2014/749175
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24648661
Print-ISSN:
0962-9351
TUM Institution:
Klinik und Poliklinik für Unfallchirurgie
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