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Titel:

Impact of STAT/SOCS mRNA expression levels after major injury.

Dokumenttyp:
Journal Article
Autor(en):
Brumann, M; Matz, M; Kusmenkov, T; Stegmaier, J; Biberthaler, P; Kanz, K-G; Mutschler, W; Bogner, V
Abstract:
Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma. The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family.20 polytraumatized patients were included. Blood samples were drawn 0 h-72 h after trauma; mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3 were quantified by qPCR.IL-10 mRNA expression increased significantly in the early postt...     »
Zeitschriftentitel:
Mediators Inflamm
Jahr:
2014
Band / Volume:
2014
Seitenangaben Beitrag:
749175
Volltext / DOI:
doi:10.1155/2014/749175
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24648661
Print-ISSN:
0962-9351
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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