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Title:

Disturbed vestibular-neck interaction in cerebellar disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kammermeier, S; Kleine, J F; Eggert, T; Krafczyk, S; Büttner, U
Abstract:
Cerebellar dysfunction results in ataxia including postural deficits. Evidence from animal experiments suggests convergence of vestibular and neck-position related inputs in cerebellar midline structures. We investigated 20 ambulatory patients with cerebellar disease for disturbed postural control using posturography during static lateral head turns. Binaural bipolar sine-wave galvanic vestibular stimulation (GVS) was used to evoke specific body movements. The Klockgether clinical score was used to assess the severity of cerebellar dysfunction (4-17 of maximal 35 points). In 12 healthy controls and seven lightly affected patients (score <8), GVS elicited physiologic alternating body sway in the head-frontal plane in seven head-on-trunk positions (0°; 30°, 45° and 60° left and right). Body sway turning with head excursion was progressively attenuated or abolished in more severely affected patients (scores 9-17; r = 0.57, p = 0.008). With most severe impairment, body sway was always in the body-frontal plane irrespective of head turn. A simple clinical test with walking under maximal head turn and closed eyes correlated with posturography data (r = 0.87, p < 0.001) and with Klockgether scores (r = 0.71, p < 0.001). Thus in cerebellar disease, head on trunk position can have a pronounced effect on postural control.
Journal title abbreviation:
J Neurol
Year:
2013
Journal volume:
260
Journal issue:
3
Pages contribution:
794-804
Language:
eng
Fulltext / DOI:
doi:10.1007/s00415-012-6707-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23081756
Print-ISSN:
0340-5354
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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