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Titel:

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Petersen, B; Wolf, M; Austermann, J; van Lent, P; Foell, D; Ahlmann, M; Kupas, V; Loser, K; Sorg, C; Roth, J; Vogl, T
Abstract:
Mrp8 and Mrp14 are endogenous alarmins amplifying inflammation via Toll-like receptor-4 (TLR-4) activation. Due to their pro-inflammatory properties, alarmins are supposed to enhance adaptive immunity via activation of dendritic cells (DCs). In contrast, analysing a model of allergic contact dermatitis (ACD) we observed a more severe disease outcome in Mrp8/14-deficient compared to wild-type mice. This unexpected phenotype was associated with an enhanced T-cell response due to an accelerated mat...     »
Zeitschriftentitel:
EMBO J
Jahr:
2013
Band / Volume:
32
Heft / Issue:
1
Seitenangaben Beitrag:
100-11
Sprache:
eng
Volltext / DOI:
doi:10.1038/emboj.2012.309
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23188082
Print-ISSN:
0261-4189
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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