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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Huber, M; Heink, S; Pagenstecher, A; Reinhard, K; Ritter, J; Visekruna, A; Guralnik, A; Bollig, N; Jeltsch, K; Heinemann, C; Wittmann, E; Buch, T; Prazeres da Costa, O; Brüstle, A; Brenner, D; Mak, TW; Mittrücker, HW; Tackenberg, B; Kamradt, T; Lohoff, M
Title:
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
Abstract:
IL-17-producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions; however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we induced EAE, a murine model of MS, in mice lacking IFN regulatory factor 4 (IRF4). IRF4-deficient mice failed to generate Tc17 and Th17 cells and were resistant to EAE. After adoptive transfer of WT CD8+ T cells and subsequent immunization for EAE induction in these mice, the CD8+ T cells developed a Tc17 phenotype...     »
Journal title abbreviation:
J Clin Invest
Year:
2013
Journal volume:
123
Journal issue:
1
Pages contribution:
247-60
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI63681
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23221338
Print-ISSN:
0021-9738
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Neurologische Klinik und Poliklinik
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