User: Guest  Login
Title:

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.

Document type:
journal article
Author(s):
Stutzbach, Lauren D; Xie, Sharon X; Naj, Adam C; Albin, Roger; Gilman, Sid; PSP Genetics Study Group; Lee, Virginia M Y; Trojanowski, John Q; Devlin, Bernie; Schellenberg, Gerard D; Höglinger, Günter U; Müller, Ulrich; Dickson, Dennis W; Rademakers, Rosa; de Silva, Rohan; Litvan, Irene; Gross, Rachel G; Hardy, John; Heutink, Peter; Hurtig, Howard I; Farrer, Matthew J; Uitti, Ryan J; Vandrovcova, Jana; van Swieten, John C; Wszolek, Zbignew K; Tolosa, Eduardo; Pastor, Pau; Revesz, Tamas; Lees, And...     »
Abstract:
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the endoplasmic reticulum's (ER) unfolded protein response (UPR). PERK is an ER membrane protein that senses unfolded protein accumulation within the ER lumen. Recentl...     »
Journal title abbreviation:
Acta Neuropathol Commun
Year:
2013
Journal volume:
1
Journal issue:
1
Pages contribution:
31
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24252572
TUM Institution:
Neurologische Klinik und Poliklinik
 BibTeX