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Titel:

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.

Dokumenttyp:
journal article
Autor(en):
Stutzbach, Lauren D; Xie, Sharon X; Naj, Adam C; Albin, Roger; Gilman, Sid; PSP Genetics Study Group; Lee, Virginia M Y; Trojanowski, John Q; Devlin, Bernie; Schellenberg, Gerard D; Höglinger, Günter U; Müller, Ulrich; Dickson, Dennis W; Rademakers, Rosa; de Silva, Rohan; Litvan, Irene; Gross, Rachel G; Hardy, John; Heutink, Peter; Hurtig, Howard I; Farrer, Matthew J; Uitti, Ryan J; Vandrovcova, Jana; van Swieten, John C; Wszolek, Zbignew K; Tolosa, Eduardo; Pastor, Pau; Revesz, Tamas; Lees, And...     »
Abstract:
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the endoplasmic reticulum's (ER) unfolded protein response (UPR). PERK is an ER membrane protein that senses unfolded protein accumulation within the ER lumen. Recentl...     »
Zeitschriftentitel:
Acta Neuropathol Commun
Jahr:
2013
Band / Volume:
1
Heft / Issue:
1
Seitenangaben Beitrag:
31
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24252572
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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