Faraco, J; Lin, L; Kornum, BR; Kenny, EE; Trynka, G; Einen, M; Rico, TJ; Lichtner, P; Dauvilliers, Y; Arnulf, I; Lecendreux, M; Javidi, S; Geisler, P; Mayer, G; Pizza, F; Poli, F; Plazzi, G; Overeem, S; Lammers, GJ; Kemlink, D; Sonka, K; Nevsimalova, S; Rouleau, G; Desautels, A; Montplaisir, J; Frauscher, B; Ehrmann, L; Högl, B; Jennum, P; Bourgin, P; Peraita-Adrados, R; Iranzo, A; Bassetti, C; Chen, WM; Concannon, P; Thompson, SD; Damotte, V; Fontaine, B; Breban, M; Gieger, C; Klopp, N; Deloukas, P; Wijmenga, C; Hallmayer, J; Onengut-Gumuscu, S; Rich, SS; Winkelmann, J; Mignot, E     «

Faraco, J; Lin, L; Kornum, BR; Kenny, EE; Trynka, G; Einen, M; Rico, TJ; Lichtner, P; Dauvilliers, Y; Arnulf, I; Lecendreux, M; Javidi, S; Geisler, P; Mayer, G; Pizza, F; Poli, F; Plazzi, G; Overeem, S; Lammers, GJ; Kemlink, D; Sonka, K; Nevsimalova, S; Rouleau, G; Desautels, A; Montplaisir, J; Frauscher, B; Ehrmann, L; Högl, B; Jennum, P; Bourgin, P; Peraita-Adrados, R; Iranzo, A; Bassetti, C; Chen, WM; Concannon, P; Thompson, SD; Damotte, V; Fontaine, B; Breban, M; Gieger, C; Klopp, N; Delouka...     »

Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H (CTSH) and Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4, also called OX40L), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease.     «

Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chr...     »