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Titel:

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation A?42 DNA vaccine for Alzheimer disease.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Lambracht-Washington, Doris; Qu, Bao-xi; Fu, Min; Anderson, Larry D; Eagar, Todd N; Stüve, Olaf; Rosenberg, Roger N
Abstract:
Immunotherapy has the potential to provide a possible treatment therapy to prevent or delay Alzheimer disease. In a clinical trial (AN1792) in which patients received this immunotherapy and received active A?1-42 peptide immunizations, treatment was stopped when 6% of patients showed signs of meningoencephalitis. Follow up on these patients led to the conclusion that the antibody response was beneficial in removing A?1-42 from brain but an accompanying inflammatory Th1 T cell response was harmfu...     »
Zeitschriftentitel:
J Neuroimmunol
Jahr:
2013
Band / Volume:
254
Heft / Issue:
1-2
Seitenangaben Beitrag:
63-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jneuroim.2012.09.008
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23036592
Print-ISSN:
0165-5728
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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