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Title:

Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5.

Document type:
Journal Article
Author(s):
Schulte, Matthias; Sorkin, Michael; Al-Benna, Sammy; Stupka, Jadwiga; Hirsch, Tobias; Daigeler, Adrien; Kesting, Marco Rainer; Steinau, Hans-Ulrich; Jacobsen, Frank; Steinstraesser, Lars
Abstract:
Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The 'Achilles heel' of adenoviral gene therapy is its immunogenicity and many aspects of adenovirus induced cutaneous immune reaction still remain unanswered, particularly the role of keratinocytes. Therefore, human keratinocytes were transfected with adenoviral DNA and cytokine expression was analyz...     »
Journal title abbreviation:
Springerplus
Year:
2013
Journal volume:
2
Journal issue:
1
Pages contribution:
234
Language:
eng
Fulltext / DOI:
doi:10.1186/2193-1801-2-234
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23750330
Print-ISSN:
2193-1801
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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