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Title:

RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and ?-CGRP deficiency.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kauther, Max D; Neuerburg, Carl; Wefelnberg, Florian; Bachmann, Hagen S; Schlepper, Rüdiger; Hilken, Gero; Broecker-Preuss, Martina; Grabellus, Florian; Schilling, Arndt F; Jäger, Marcus; Wedemeyer, Christian
Abstract:
An aging population with higher bone turnover intensifies the need for joint replacement surgery. However, particle-induced osteolysis (PIO) remains a major cause of early implant loosening. Differences in bone remodeling between young and aged Calcitonin (CT)- and ?-CGRP (Calcitonin gene-related peptide)-deficient mice (Calca(-/-)) might modify our previous findings regarding CT/?-CGRP in PIO. This may have important implications for PIO in an aging population. Four groups of twelve-month-old w...     »
Journal title abbreviation:
Biomaterials
Year:
2013
Journal volume:
34
Journal issue:
12
Pages contribution:
2911-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2013.01.034
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23357366
Print-ISSN:
0142-9612
TUM Institution:
Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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