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Title:

Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF receptor.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Vetter, Alexandra; Virdi, Kulpreet S; Espenlaub, Sigrid; Rödl, Wolfgang; Wagner, Ernst; Holm, Per S; Scheu, Christina; Kreppel, Florian; Spitzweg, Christine; Ogris, Manfred
Abstract:
Adenovirus type 5 (Ad) is an efficient gene vector with high gene transduction potential, but its efficiency depends on its native cell receptors coxsackie- and adenovirus receptor (CAR) for cell attachment and ?(v)?(3/5) integrins for internalization. To enable transduction of CAR negative cancer cell lines, we have coated the negatively charged Ad by noncovalent charge interaction with cationic PAMAM (polyamidoamine) dendrimers. The specificity for tumor cell infection was increased by targeti...     »
Journal title abbreviation:
Mol Pharm
Year:
2013
Journal volume:
10
Journal issue:
2
Pages contribution:
606-18
Language:
eng
Fulltext / DOI:
doi:10.1021/mp300366f
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23281933
Print-ISSN:
1543-8384
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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