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Title:

EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene.

Document type:
Journal Article
Author(s):
Grünwald, GK; Vetter, A; Klutz, K; Willhauck, MJ; Schwenk, N; Senekowitsch-Schmidtke, R; Schwaiger, M; Zach, C; Wagner, E; Göke, B; Holm, PS; Ogris, M; Spitzweg, C
Abstract:
We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus. To further improve shielding and targeting we physically coated replication-selective adenoviruses carrying the hNIS gene with a conjugate consisting of cationic poly(amidoamine) (PAMAM) dendrimer linked to the peptidic, epidermal growth factor receptor (EGFR)-specific ligand...     »
Journal title abbreviation:
Mol Ther Nucleic Acids
Year:
2013
Journal volume:
2
Pages contribution:
e131
Language:
eng
Fulltext / DOI:
doi:10.1038/mtna.2013.58
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24193032
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Nuklearmedizin
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