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Title:

Systemic TNF? gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Author(s):
Su, Baowei; Cengizeroglu, Arzu; Farkasova, Katarina; Viola, Joana R; Anton, Martina; Ellwart, Joachim W; Haase, Rudolf; Wagner, Ernst; Ogris, Manfred
Abstract:
Tumor necrosis factor alpha (TNF?) is a potent antitumoral cytokine, either killing tumor cells directly or affecting the tumor vasculature leading to enhanced accumulation of macromolecular drugs. Due to dose limiting side effects systemic administration of TNF? protein at therapeutically active doses is precluded. With gene vectors, tumor restricted TNF? expression can be achieved and in principle synergize with chemotherapy. Synthetic gene carriers based on polyamines were intravenously injec...     »
Journal title abbreviation:
Mol Ther
Year:
2013
Journal volume:
21
Journal issue:
2
Pages contribution:
300-8
Language:
eng
Fulltext / DOI:
doi:10.1038/mt.2012.229
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23299796
Print-ISSN:
1525-0016
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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