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Title:

Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Grünwald, GK; Vetter, A; Klutz, K; Willhauck, MJ; Schwenk, N; Senekowitsch-Schmidtke, R; Schwaiger, M; Zach, C; Wagner, E; Göke, B; Holm, PS; Ogris, M; Spitzweg, C
Abstract:
Currently, major limitations for the clinical application of adenovirus-mediated gene therapy are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-adenovirus receptor (CAR), and adenovirus sequestration by the liver. In the current study, we used the sodium iodide symporter (NIS) as a theranostic gene to investigate whether coating of adenovirus with synthetic dendrimers could be useful to overcome these hurdles in order to develop adenoviral vectors for combina...     »
Journal title abbreviation:
J Nucl Med
Year:
2013
Journal volume:
54
Journal issue:
8
Pages contribution:
1450-7
Language:
eng
Fulltext / DOI:
doi:10.2967/jnumed.112.115493
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23843567
Print-ISSN:
0161-5505
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Nuklearmedizin
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