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Titel:

Systemic TNF? gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Su, Baowei; Cengizeroglu, Arzu; Farkasova, Katarina; Viola, Joana R; Anton, Martina; Ellwart, Joachim W; Haase, Rudolf; Wagner, Ernst; Ogris, Manfred
Abstract:
Tumor necrosis factor alpha (TNF?) is a potent antitumoral cytokine, either killing tumor cells directly or affecting the tumor vasculature leading to enhanced accumulation of macromolecular drugs. Due to dose limiting side effects systemic administration of TNF? protein at therapeutically active doses is precluded. With gene vectors, tumor restricted TNF? expression can be achieved and in principle synergize with chemotherapy. Synthetic gene carriers based on polyamines were intravenously injec...     »
Zeitschriftentitel:
Mol Ther
Jahr:
2013
Band / Volume:
21
Heft / Issue:
2
Seitenangaben Beitrag:
300-8
Sprache:
eng
Volltext / DOI:
doi:10.1038/mt.2012.229
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23299796
Print-ISSN:
1525-0016
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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