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Title:

Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge.

Document type:
Comparative Study; Journal Article; Article
Author(s):
Baumann, Ralf; Rabaszowski, Matthaeus; Stenin, Igor; Tilgner, Lisa; Scheckenbach, Kathrin; Wiltfang, Jens; Schipper, Joerg; Chaker, Adam; Wagenmann, Martin
Abstract:
Allergic rhinitis is an inflammatory disease characterized by local overproduction of type 2 cytokines and tissue eosinophilia. Recent research suggests the involvement of additional cytokines such as IL-17, chemokine (C-C motif) ligand (CCL) 26/eotaxin-3, and CCL13/monocyte chemoattractant protein-4 (MCP-4) in its pathophysiology. Furthermore, bronchial epithelial cells treated with IL-17 and type 2 cytokines distinctively up-regulated eotaxin-3 gene expression. In this study we investigated th...     »
Journal title abbreviation:
Am J Rhinol Allergy
Year:
2013
Journal volume:
27
Journal issue:
4
Pages contribution:
266-72
Language:
eng
Fulltext / DOI:
doi:10.2500/ajra.2013.27.3913
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23883806
Print-ISSN:
1945-8924
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik; Molekulare Allergologie (Prof. Schmidt-Weber)
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