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Titel:

Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
Autor(en):
Li, Wei; Tsen, Fred; Sahu, Divya; Bhatia, Ayesha; Chen, Mei; Multhoff, Gabriele; Woodley, David T
Abstract:
Despite extensive investigative studies and clinical trials over the past two decades, we still do not understand why cancer cells are more sensitive to the cellular toxicity of Hsp90 inhibitors than normal cells. We still do not understand why only some cancer cells are sensitive to the Hsp90 inhibitors. Based on studies of the past few years, we argue that the selected sensitivity of cancer cells to Hsp90 inhibitors, such as 17-N-allylamino-17-demethoxygeldanamycin, is due to inhibition of the...     »
Zeitschriftentitel:
Int Rev Cell Mol Biol
Jahr:
2013
Band / Volume:
303
Seitenangaben Beitrag:
203-35
Sprache:
eng
Volltext / DOI:
doi:10.1016/B978-0-12-407697-6.00005-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23445811
Print-ISSN:
1937-6448
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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