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Titel:

Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Gaca, Sebastian; Reichert, Sebastian; Multhoff, Gabriele; Wacker, Matthias; Hehlgans, Stephanie; Botzler, Claus; Gehrmann, Matthias; Rödel, Claus; Kreuter, Jörg; Rödel, Franz
Abstract:
Nanoparticles (NP) as carriers for anti-cancer drugs have shown great promise. Specific targeting of NP to malignant cells, however, remains an unsolved problem. Conjugation of antibodies specific for tumor membrane antigens to NP represents one approach to improve specificity and to increase therapeutic efficacy. In the present study, for the first time a novel membrane heat shock protein (Hsp70)-specific antibody (cmHsp70.1) was coupled to human serum albumin (HSA) NP, loaded with microRNA (mi...     »
Zeitschriftentitel:
J Control Release
Jahr:
2013
Band / Volume:
172
Heft / Issue:
1
Seitenangaben Beitrag:
201-6
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jconrel.2013.08.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24008150
Print-ISSN:
0168-3659
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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