Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?

Title:: Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?
Document type:: Journal Article; Review
Author(s):: Mayer, Arnulf; Vaupel, Peter
Abstract:: This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible "targeted" therapeutic interventions.
Journal title abbreviation:: Adv Exp Med Biol
Year:: 2013
Journal volume:: 789
Pages contribution:: 203-9
Language:: eng
Fulltext / DOI:: doi:10.1007/978-1-4614-7411-1_28
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/23852496
Print-ISSN:: 0065-2598
TUM Institution:: Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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