Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?

Titel:: Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?
Dokumenttyp:: Journal Article; Review
Autor(en):: Mayer, Arnulf; Vaupel, Peter
Abstract:: This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible "targeted" therapeutic interventions.
Zeitschriftentitel:: Adv Exp Med Biol
Jahr:: 2013
Band / Volume:: 789
Seitenangaben Beitrag:: 203-9
Sprache:: eng
Volltext / DOI:: doi:10.1007/978-1-4614-7411-1_28
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/23852496
Print-ISSN:: 0065-2598
TUM Einrichtung:: Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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