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Title:

Interferon-? production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
del Fresno, Carlos; Soulat, Didier; Roth, Susanne; Blazek, Katrina; Udalova, Irina; Sancho, David; Ruland, Jürgen; Ardavín, Carlos
Abstract:
Type I interferon (IFN) is crucial during infection through its antiviral properties and by coordinating the immunocompetent cells involved in antiviral or antibacterial immunity. Type I IFN (IFN-? and IFN-?) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7. IFN-? production after fungal infection was recently reported, although the underlying mechanism remains controversial....     »
Journal title abbreviation:
Immunity
Year:
2013
Journal volume:
38
Journal issue:
6
Pages contribution:
1176-86
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2013.05.010
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23770228
Print-ISSN:
1074-7613
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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