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Titel:

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gorrini, Chiara; Baniasadi, Pegah S; Harris, Isaac S; Silvester, Jennifer; Inoue, Satoshi; Snow, Bryan; Joshi, Purna A; Wakeham, Andrew; Molyneux, Sam D; Martin, Bernard; Bouwman, Peter; Cescon, David W; Elia, Andrew J; Winterton-Perks, Zoe; Cruickshank, Jennifer; Brenner, Dirk; Tseng, Alan; Musgrave, Melinda; Berman, Hal K; Khokha, Rama; Jonkers, Jos; Mak, Tak W; Gauthier, Mona L
Abstract:
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependent antioxidant signaling by physically interacting with Nrf2 and promoting its stability and activation. BRCA1-deficient mouse primary mammary epithelial cells show low expression of Nrf2-regulated ant...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2013
Band / Volume:
210
Heft / Issue:
8
Seitenangaben Beitrag:
1529-44
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20121337
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23857982
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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