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Titel:

The Nlrp3 inflammasome regulates acute graft-versus-host disease.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Jankovic, Dragana; Ganesan, Jayanthi; Bscheider, Michael; Stickel, Natalie; Weber, Felix C; Guarda, Greta; Follo, Marie; Pfeifer, Dietmar; Tardivel, Aubry; Ludigs, Kristina; Bouazzaoui, Abdellatif; Kerl, Katrin; Fischer, Julius C; Haas, Tobias; Schmitt-Gräff, Annette; Manoharan, Anand; Müller, Leonard; Finke, Jürgen; Martin, Stefan F; Gorka, Oliver; Peschel, Christian; Ruland, Jürgen; Idzko, Marco; Duyster, Justus; Holler, Ernst; French, Lars E; Poeck, Hendrik; Contassot, Emmanuel; Zeiser, Rober...     »
Abstract:
The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host disease (GvHD), a severe complication accompanied by high mortality rates. Yet, the molecular mechanisms initiating this disease remain poorly defined. In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1? production and that gastrointestinal decontamination and uri...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2013
Band / Volume:
210
Heft / Issue:
10
Seitenangaben Beitrag:
1899-910
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20130084
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23980097
Print-ISSN:
0022-1007
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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