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Titel:

Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Chételat, G; Landeau, B; Salmon, E; Yakushev, I; Bahri, MA; Mézenge, F; Perrotin, A; Bastin, C; Manrique, A; Scheurich, A; Scheckenberger, M; Desgranges, B; Eustache, F; Fellgiebel, A
Abstract:
Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related alteration of white matter (WM) structural integrity and/or functional connectivity. FDG-PET data from 40 young and 57 elderly healthy participants from two research centers (n=49/48 in Center 1/2) were analyzed. WM volume from T1-weighted MRI (Center 1), fractional anisotropy from diffusion-tenso...     »
Zeitschriftentitel:
Neuroimage
Jahr:
2013
Band / Volume:
76
Seitenangaben Beitrag:
167-77
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.neuroimage.2013.03.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23518010
Print-ISSN:
1053-8119
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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