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Title:

A randomized phase II study of pemetrexed in combination with cisplatin or carboplatin as first-line therapy for patients with locally advanced or metastatic non-small-cell lung cancer.

Document type:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Author(s):
Schuette, Wolfgang H W; Gröschel, Andreas; Sebastian, Martin; Andreas, Stefan; Müller, Thomas; Schneller, Folker; Guetz, Sylvia; Eschbach, Corinna; Bohnet, Sabine; Leschinger, Monika I; Reck, Martin
Abstract:
Pemetrexed plus cisplatin was approved for first-line treatment of non-small-cell lung cancer (NSCLC) in patients with nonsquamous histology after initiation of this study. This phase II study evaluated pemetrexed plus cisplatin and pemetrexed plus carboplatin as first-line treatments for stage IIIB/IV NSCLC.The patients were randomized (1:1) to 2 parallel arms: pemetrexed (500 mg/m(2)) plus cisplatin (75 mg/m(2)) or pemetrexed (500 mg/m(2)) plus carboplatin (area under the curve 6) day 1 every...     »
Journal title abbreviation:
Clin Lung Cancer
Year:
2013
Journal volume:
14
Journal issue:
3
Pages contribution:
215-23
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cllc.2012.10.001
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23332288
Print-ISSN:
1525-7304
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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