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Title:

Antitumor T cell responses in bladder cancer are directed against a limited set of antigens and are modulated by regulatory T cells and routine treatment approaches.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Horn, Thomas; Grab, Jessica; Schusdziarra, Julia; Schmid, Sebastian; Maurer, Tobias; Nawroth, Roman; Wolf, Petra; Pritsch, Maria; Gschwend, Jürgen E; Kübler, Hubert R; Beckhove, Philipp
Abstract:
Regulatory T cells (Tregs) play a key role in cancer immune escape. We identified target antigens of spontaneous tumor-specific T cell responses in urothelial carcinoma (UC) and evaluated their modulation by treatment and Treg. We determined Treg target antigens in UC. Fifty-six UC and 13 control patients were prospectively enrolled. Blood was drawn before and after routine treatment. Changes in Treg frequency were measured by fluorescence cytometry and the T effector cell (Teff) response agains...     »
Journal title abbreviation:
Int J Cancer
Year:
2013
Journal volume:
133
Journal issue:
9
Pages contribution:
2145-56
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.28233
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23625723
Print-ISSN:
0020-7136
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Urologische Klinik und Poliklinik
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