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Titel:

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors.

Dokumenttyp:
Journal Article
Autor(en):
Multhoff, G; Vaupel, P
Abstract:
The immature, chaotic microvasculature of most solid tumors can present a significant impediment to blood-borne delivery, uneven distribution, and compromised penetration of macromolecular anticancer drugs and diagnostic agents from tumor microvessels across the interstitial space to cancer cells. To reach viable tumor cells in relevant concentrations, macromolecular agents are confronted with several barriers to vascular, transvascular, and interstitial transport. Amongst those (1) heterogeneou...     »
Zeitschriftentitel:
Front Oncol
Jahr:
2012
Band / Volume:
2
Seitenangaben Beitrag:
165
Sprache:
eng
Volltext / DOI:
doi:10.3389/fonc.2012.00165
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23162794
Print-ISSN:
2234-943X
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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