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Titel:

Nuclear matrix protein 22 for bladder cancer detection: comparative analysis of the BladderChek® and ELISA.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hatzichristodoulou, G; Kubler, H; Schwaibold, H; Wagenpfeil, S; Eibauer, C; Hofer, C; Gschwend, J; Treiber, U
Abstract:
To compare nuclear matrix protein 22 expression by BladderChek® and ELISA, as urine-based assays for bladder cancer (BC) detection.Urine samples of 100 BC patients and 100 controls were analyzed. Comparative statistical evaluations were based on sensitivity and specificity.Seventy-one patients had primary and 29 recurrent BC. The sensitivity of BladderChek® was significantly higher compared to ELISA in the overall cancer cohort and in patients with primary BC (p<0.0001 and p=0.0001, respectively). Both tests demonstrated significant correlation of sensitivities and tumor stage/grade for the overall cancer cohort and for patients with primary BC. Both tests had specificity values of 100% in healthy individuals. Specificity was 93% for BladderChek® and 99% for ELISA in patients with benign diseases (p=0.048).BladderChek® may be clinically more useful for BC detection. Due to high specificity, BladderChek® could be used for high-risk screening. However, due to its low sensitivity, BladderChek® cannot replace but only complement cystoscopy for BC detection.
Zeitschriftentitel:
Anticancer Res
Jahr:
2012
Band / Volume:
32
Heft / Issue:
11
Seitenangaben Beitrag:
5093-7
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23155286
Print-ISSN:
0250-7005
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Urologische Klinik und Poliklinik
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