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Title:

Essential role of interleukin-6 in post-stroke angiogenesis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Gertz, K; Kronenberg, G; Kälin, RE; Baldinger, T; Werner, C; Balkaya, M; Eom, GD; Hellmann-Regen, J; Krober, J; Miller, KR; Lindauer, U; Laufs, U; Dirnagl, U; Heppner, FL; Endres, M
Abstract:
Ambivalent effects of interleukin-6 on the pathogenesis of ischaemic stroke have been reported. However, to date, the long-term actions of interleukin-6 after stroke have not been investigated. Here, we subjected interleukin-6 knockout (IL-6(-/-)) and wild-type control mice to mild brain ischaemia by 30-min filamentous middle cerebral artery occlusion/reperfusion. While ischaemic tissue damage was comparable at early time points, IL-6(-/-) mice showed significantly increased chronic lesion volum...     »
Journal title abbreviation:
Brain
Year:
2012
Journal volume:
135
Journal issue:
Pt 6
Pages contribution:
1964-80
Language:
eng
Fulltext / DOI:
doi:10.1093/brain/aws075
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22492561
Print-ISSN:
0006-8950
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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