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Titel:

PSEA: Phenotype Set Enrichment Analysis-A New Method for Analysis of Multiple Phenotypes.

Dokumenttyp:
Journal Article; Article
Autor(en):
Ried, JS; Döring, A; Oexle, K; Meisinger, C; Winkelmann, J; Klopp, N; Meitinger, T; Peters, A; Suhre, K; Wichmann, HE; Gieger, C
Abstract:
Most genome-wide association studies (GWAS) are restricted to one phenotype, even if multiple related or unrelated phenotypes are available. However, an integrated analysis of multiple phenotypes can provide insight into their shared genetic basis and may improve the power of association studies. We present a new method, called "phenotype set enrichment analysis" (PSEA), which uses ideas of gene set enrichment analysis for the investigation of phenotype sets. PSEA combines statistics of univaria...     »
Zeitschriftentitel:
Genet Epidemiol
Jahr:
2012
Band / Volume:
36
Heft / Issue:
3
Seitenangaben Beitrag:
244-52
Sprache:
eng
Volltext / DOI:
doi:10.1002/gepi.21617
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22714936
Print-ISSN:
0741-0395
TUM Einrichtung:
Institut für Humangenetik; Neurologische Klinik und Poliklinik
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