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Title:

Availability, not respiratory capacity governs oxygen consumption of solid tumors.

Document type:
Journal Article; Review
Author(s):
Vaupel, P; Mayer, A
Abstract:
Contrary to conventional belief, the mitochondria of most cancer cells usually function normally, i.e., their respiratory capacity is not fundamentally impaired as compared to normal cells. Strong evidence against the misconception of mitochondrial dysfunction is provided by in vivo data clearly showing that O(2) availability is the major determinant of the O(2) consumption rate of cancer cells, independent of the means for increasing availability (e.g., by increasing blood flow or by elevating...     »
Journal title abbreviation:
Int J Biochem Cell Biol
Year:
2012
Journal volume:
44
Journal issue:
9
Pages contribution:
1477-81
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biocel.2012.05.019
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22664330
Print-ISSN:
1357-2725
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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