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Title:

Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Laubenthal, J; Zlobinskaya, O; Poterlowicz, K; Baumgartner, A; Gdula, MR; Fthenou, E; Keramarou, M; Hepworth, SJ; Kleinjans, JC; van Schooten, FJ; Brunborg, G; Godschalk, RW; Schmid, TE; Anderson, D
Abstract:
The relevance of preconceptional and prenatal toxicant exposures for genomic stability in offspring is difficult to analyze in human populations, because gestational exposures usually cannot be separated from preconceptional exposures. To analyze the roles of exposures during gestation and conception on genomic stability in the offspring, stability was assessed via the Comet assay and highly sensitive, semiautomated confocal laser scans of ?H2AX foci in cord, maternal, and paternal blood as well...     »
Journal title abbreviation:
FASEB J
Year:
2012
Journal volume:
26
Journal issue:
10
Pages contribution:
3946-56
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.11-201194
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22730438
Print-ISSN:
0892-6638
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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