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Titel:

(-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Härdtner, C; Multhoff, G; Falk, W; Radons, J
Abstract:
Despite their toxic side effects prostaglandin H(2) synthase-2 (PGHS-2) inhibitors hold promise for cancer chemoprevention. In order to overcome adverse effects lower doses of PGHS-2 inhibitors could be applied in combination with other agents exhibiting complementary effects. Herein, the effects of the PGHS-2-specific inhibitor celecoxib either alone or in combination with the green tea-derived catechin (-)-epigallocatechin-3-gallate (EGCG) were studied on the expression of interleukin (IL)-1-i...     »
Zeitschriftentitel:
Eur J Pharmacol
Jahr:
2012
Band / Volume:
684
Heft / Issue:
1-3
Seitenangaben Beitrag:
36-43
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ejphar.2012.03.039
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22497997
Print-ISSN:
0014-2999
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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