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Titel:

Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma.

Dokumenttyp:
Journal Article
Autor(en):
Mayer, A; Schneider, F; Vaupel, P; Sommer, C; Schmidberger, H
Abstract:
Hypoxia is an important factor mediating tumor progression and therapeutic resistance, in part through proteome changes mediated by the transcription factor hypoxia-inducible factor (HIF)-1. Since glioblastoma multiforme is the epitome of a highly aggressive tumor entity, while lower-grade astrocytomas often show a prolonged clinical course, a profound difference in the extent of hypoxic tissue areas and corresponding magnitude of HIF-1 activity may exist between these entities. In this study, t...     »
Zeitschriftentitel:
Int J Oncol
Jahr:
2012
Band / Volume:
41
Heft / Issue:
4
Seitenangaben Beitrag:
1260-70
Sprache:
eng
Volltext / DOI:
doi:10.3892/ijo.2012.1555
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22825389
Print-ISSN:
1019-6439
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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