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Titel:

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Zhang, H; Zou, B; Yu, H; Moretti, A; Wang, X; Yan, W; Babcock, JJ; Bellin, M; McManus, OB; Tomaselli, G; Nan, F; Laugwitz, KL; Li, M
Abstract:
Long QT syndrome (LQTS) is a genetic disease characterized by a prolonged QT interval in an electrocardiogram (ECG), leading to higher risk of sudden cardiac death. Among the 12 identified genes causal to heritable LQTS, ~90% of affected individuals harbor mutations in either KCNQ1 or human ether-a-go-go related genes (hERG), which encode two repolarizing potassium currents known as I(Ks) and I(Kr). The ability to quantitatively assess contributions of different current components is therefore i...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2012
Band / Volume:
109
Heft / Issue:
29
Seitenangaben Beitrag:
11866-71
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1205266109
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22745159
Print-ISSN:
0027-8424
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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