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Titel:

The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Diebold, I; Petry, A; Sabrane, K; Djordjevic, T; Hess, J; Gorlach, A
Abstract:
Urotensin-II (U-II) has been considered as one of the most potent vasoactive peptides, although its physiological and pathophysiological role is still not finally resolved. Recent evidence suggests that it promotes angiogenic responses in endothelial cells, although the underlying signalling mechanisms are unclear. Reactive oxygen species derived from NADPH oxidases are major signalling molecules in the vasculature. Because NOX2 is functional in endothelial cells, we investigated the role of the...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2012
Band / Volume:
125
Heft / Issue:
Pt 4
Seitenangaben Beitrag:
956-64
Sprache:
eng
Volltext / DOI:
doi:10.1242/jcs.094060
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22399808
Print-ISSN:
0021-9533
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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