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Title:

Inhibition of endothelial nitric oxyde synthase increases capillary formation via Rac1-dependent induction of hypoxia-inducible factor-1? and plasminogen activator inhibitor-1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Petry, A; BelAiba, RS; Weitnauer, M; Gorlach, A
Abstract:
Disruption of endothelial homeostasis results in endothelial dysfunction, characterised by a dysbalance between nitric oxide (NO) and reactive oxygen species (ROS) levels often accompanied by a prothrombotic and proproliferative state. The serine protease thrombin not only is instrumental in formation of the fibrin clot, but also exerts direct effects on the vessel wall by activating proliferative and angiogenic responses. In endothelial cells, thrombin can induce NO as well as ROS levels. Howev...     »
Journal title abbreviation:
Thromb Haemost
Year:
2012
Journal volume:
108
Journal issue:
5
Pages contribution:
849-62
Language:
eng
Fulltext / DOI:
doi:10.1160/TH12-04-0277
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23014943
Print-ISSN:
0340-6245
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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