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Titel:

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rzymski, T; Petry, A; Kra?un, D; Ries, F; Pike, L; Harris, AL; Gorlach, A
Abstract:
The family of ADAM (a disintegrin and metalloproteinase) proteins has been implicated in tumor initiation and progression. ADAM17/tumor necrosis factor-? (TNF?)-converting enzyme (TACE) has been initially recognized to release TNF? as well as its receptors (TNFRs) from the membrane. ADAM17, TNF? and TNFR have been found upregulated in cancer patients, although the underlying mechanisms remain largely unknown. As hypoxia is a hallmark of cancer that can lead to severe stress conditions accumulati...     »
Zeitschriftentitel:
Oncogene
Jahr:
2012
Band / Volume:
31
Heft / Issue:
31
Seitenangaben Beitrag:
3621-34
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2011.522
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22105359
Print-ISSN:
0950-9232
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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